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Retinoids as inhibitors of ortho-aminoazotoluene-induced mutagenesis in the Salmonella/liver microsome test.

作者信息

Busk L, Ahlborg U G

出版信息

Mutat Res. 1982 May-Jun;104(4-5):225-31. doi: 10.1016/0165-7992(82)90148-8.

DOI:10.1016/0165-7992(82)90148-8
PMID:7050684
Abstract

Earlier, we reported that vitamin A (retinol), in vitro, exhibits a strong inhibitory effect on the mutagenicity of aflatoxin B1 in the Ames Salmonella/microsome test. This paper reports the same inhibitory effect on the mutagenicity of an aminoazo dye, ortho-aminoazotoluene. Furthermore, the inhibitory effect was exerted by retinol esters such as retinol acetate and retinol palmitate, the latter being the physiological storage form of vitamin A. The inhibition is interpreted as an effect on the mixed-function oxidases that convert ortho-aminoazotoluene to its ultimate mutagenic form.

摘要

相似文献

1
Retinoids as inhibitors of ortho-aminoazotoluene-induced mutagenesis in the Salmonella/liver microsome test.
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2
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Mutat Res. 1999 Jul 21;444(1):235-48. doi: 10.1016/s1383-5718(99)00098-4.

引用本文的文献

1
Effects of vitamin A on the metabolism and mutagenicity of 2AAF in vitro and on the covalent binding to rat liver DNA/RNA in vivo.维生素A对2-乙酰氨基芴在体外的代谢和致突变性以及在体内与大鼠肝脏DNA/RNA共价结合的影响。
Arch Toxicol. 1985 Aug;57(3):178-83. doi: 10.1007/BF00290884.