Benoist M, Deburge A, Rigod A, Busson J, Cauchoix J
Nouv Presse Med. 1982 Jun 12;11(28):2121-4.
A proteolytic enzyme was used to dissolve the nucleus pulposus in 140 cases of sciatica from herniated lumbar disc. The results were satisfactory in 75% of 120 patients followed up for more than 6 months. This percentage of success, similar to that obtained with surgical excision of the disc, can only be achieved with a rigourous technique and, more importantly, with strict selection of the patients. Chemonucleolysis is indicated only for patients with unquestionable clinical and radiological evidence of herniated disc, in which case it can be considered as the ultimate medical treatment of sciatica associated with this lesion. No serious complications were observed in our series, but the risk of allergic reaction must be borne in mind.
采用一种蛋白水解酶溶解140例腰椎间盘突出症所致坐骨神经痛患者的髓核。在随访6个月以上的120例患者中，75%效果满意。这一成功率与椎间盘手术切除的成功率相似，只有采用严格的技术，更重要的是，严格挑选患者才能实现。化学髓核溶解术仅适用于有明确临床和影像学证据证明椎间盘突出的患者，在这种情况下，可将其视为与该病变相关的坐骨神经痛的最终内科治疗方法。我们的系列研究中未观察到严重并发症，但必须牢记过敏反应的风险。
