Canal N, Smirne S, Comi G, Guidobono F, Pecile A, Caviezel F
Acta Neurol Belg. 1982 May-Jun;82(3):178-84.
Basal and stimulated GH and PRL secretions have been studied in four patients with myotonic dystrophy. High values of basal plasma GH have been occasionally found in two patients. Abnormal plasma GH responses were coexisting with normal ones after each stimulus (oral l-dopa, oral glucose load, arginine infusion, i.v. insulin, i.v. metoclopramide). Basal plasma PRL levels were normal in all patients as well as responses to different stimuli except the response to insulin-induced hypoglycaemia that was abnormal in three patients out of four. It is concluded that in myotonic dystrophy hypothalamic regulatory mechanisms of pituitary functions may be altered because of known thalamic lesions or yet unrecognized hypothalamic ones.
对4例强直性肌营养不良患者的基础及刺激状态下的生长激素（GH）和催乳素（PRL）分泌情况进行了研究。偶尔在2例患者中发现基础血浆GH值较高。每次刺激（口服左旋多巴、口服葡萄糖负荷、精氨酸输注、静脉注射胰岛素、静脉注射甲氧氯普胺）后，异常的血浆GH反应与正常反应并存。所有患者的基础血浆PRL水平均正常，对不同刺激的反应也正常，但4例患者中有3例对胰岛素诱导的低血糖反应异常。得出的结论是，在强直性肌营养不良中，由于已知的丘脑病变或尚未识别的下丘脑病变，垂体功能的下丘脑调节机制可能会发生改变。
