伴有病毒样颗粒表现的克雅氏病

Creutzfeldt-Jakob disease with demonstration of virus-like particles.

作者信息

Shibayama Y, Sakaguchi Y, Nakata K, Goto T, Nakai M, Takai T, Shirakata S

出版信息

Acta Pathol Jpn. 1982 Jul;32(4):695-702. doi: 10.1111/j.1440-1827.1982.tb02071.x.

DOI:10.1111/j.1440-1827.1982.tb02071.x

Abstract

Two kinds of virus-like particles, doughnut-shaped particles and particles with dense core, were discovered in a brain tissue from a patient with Creutzfeldt-Jakob disease. The two types of virus-like particles are similar to immature type C and type C particles. although no direct relationship between Creutzfeldt-Jakob disease and these virus-like particles can be established, these facts may suggest that viruses play some role in the pathogenesis of Creutzfeldt-Jakob disease.

摘要

在一名克雅氏病患者的脑组织中发现了两种病毒样颗粒，即甜甜圈状颗粒和具有致密核心的颗粒。这两种病毒样颗粒类似于未成熟的C型颗粒和C型颗粒。尽管克雅氏病与这些病毒样颗粒之间无法建立直接联系，但这些事实可能表明病毒在克雅氏病的发病机制中发挥了一定作用。