Schmekel B, Hällgren R, Stålenheim G, Venge P
Acta Med Scand. 1982;211(5):393-9. doi: 10.1111/j.0954-6820.1982.tb01968.x.
The present study was carried out to compare radiological and physiological changes in sarcoidosis with biochemical markers for inflammatory cell populations. Of 53 patients with sarcoidosis, 28 had respiratory symptoms and 30 past or present bilateral hilar adenopathy without symptoms. A clinical score based on lung function tests and radiological findings correlated well with elevations of lysozyme and beta2-microglobulin in serum, indicating increased inflammatory cell activity in patients with more severe lung affection. A covariation between beta2-microglobulin and lysozyme was found, suggesting concomitant activation of macrophages and lymphocytes in sarcoidosis. Serum levels of lactoferrin were elevated in patients with a disease of short duration but did not correlate with the severity of the lung affection. The closing volume also seems to be abnormal in the early course of the disease, while elevated lysozyme and beta2-microglobulin levels rather seem to reflect the extent of the pulmonary affection.
本研究旨在比较结节病的放射学和生理学变化与炎症细胞群体的生化标志物。53例结节病患者中，28例有呼吸道症状，30例有既往或目前无症状的双侧肺门淋巴结肿大。基于肺功能测试和放射学结果的临床评分与血清中溶菌酶和β2-微球蛋白升高密切相关，表明肺部病变较严重的患者炎症细胞活性增加。发现β2-微球蛋白和溶菌酶之间存在协变，提示结节病中巨噬细胞和淋巴细胞同时被激活。病程短的患者血清乳铁蛋白水平升高，但与肺部病变的严重程度无关。在疾病早期，闭合容积似乎也异常，而溶菌酶和β2-微球蛋白水平升高似乎更能反映肺部病变的程度。
