Berenson G S, Frank G C, Hunter S M, Srinivasan S R, Voors A W, Webber L S
Am J Dis Child. 1982 Sep;136(9):855-62. doi: 10.1001/archpedi.1982.03970450097024.
There is evidence that atherosclerosis, coronary artery disease, and essential hypertension begin early in life. The Bogalusa (La) Heart Study has examined cardiovascular risk factors and their determinants during the pediatric age span in a total community study. Reliable measurements were obtained and then analyzed to identify "tracking" of risk factors over time and clusters or aggregations of various risk factors at high levels. Serum lipoprotein levels, obesity, BP, and plasma insulin levels were all correlated after a glucose load, implying causal interrelationships. Although such relationship are only partly elucidated, the associations potentially enhance premature atherosclerosis. Certain kinds of behavior, for example cigarette smoking and type A behavior, may also contribute to early coronary artery disease. Our observations suggest that practicing physicians should assess risk factors in children and encourage changes in life-style to combat the high incidence of coronary artery disease and essential hypertension in the United States.
有证据表明动脉粥样硬化、冠状动脉疾病和原发性高血压在生命早期就已开始。博加卢萨（路易斯安那州）心脏研究在一项全社区研究中，对儿童期的心血管危险因素及其决定因素进行了调查。获取了可靠的测量数据，然后进行分析，以确定危险因素随时间的“追踪”情况以及各种危险因素在高水平时的聚集或聚合情况。葡萄糖负荷后，血清脂蛋白水平、肥胖、血压和血浆胰岛素水平均具有相关性，这意味着存在因果相互关系。尽管这种关系仅得到部分阐明，但这些关联可能会加剧过早发生的动脉粥样硬化。某些行为，例如吸烟和A型行为，也可能导致早期冠状动脉疾病。我们的观察结果表明，执业医师应该评估儿童的危险因素，并鼓励改变生活方式，以应对美国冠状动脉疾病和原发性高血压的高发病率。
