Schemmel R A, Teague R J, Bray G A
Am J Physiol. 1982 Sep;243(3):R347-53. doi: 10.1152/ajpregu.1982.243.3.R347.
S 5B/Pl rats were tested for their susceptibility to develop obesity when 1) ovariectomized, 2) given injections of insulin, and 3) given a sucrose solution to drink instead of water. The results obtained in Osborne-Mendel rats susceptible to dietary obesity when fed a high-fat diet were compared to those obtained in the S 5B/Pl rats not susceptible to dietary obesity. When tested at the end of 10 wk, ovariectomized rats of both strains had gained 22% more weight than sham-operated controls. Replacement estradiol injections suppressed food intake in both strains with a concomitant loss in body weight. Osborne-Mendel rats tolerated at least 40 U of U-100 protamine zinc insulin/day and rapidly gained weight whereas S 5B/Pl rats given more than 2 U U-100 protamine zinc insulin/day died. Compared to female Osborne-Mendel rats drinking water, rats drinking a sucrose solution accumulated more body fat and had higher levels of serum immunoreactive insulin and lower levels of serum free fatty acids. The substitution of a sucrose solution for plain drinking water suppressed weight gain in S 5B/Pl rats.
对S 5B/Pl品系大鼠进行了如下测试，以观察其在以下三种情况下发生肥胖的易感性：1）卵巢切除；2）注射胰岛素；3）给予蔗糖溶液饮用而非饮水。将喂食高脂饮食时易患饮食性肥胖的奥斯本-孟德尔大鼠所获得的结果，与不易患饮食性肥胖的S 5B/Pl品系大鼠所获得的结果进行比较。在10周结束时进行测试时，两个品系的卵巢切除大鼠比假手术对照组体重增加了22%。补充雌二醇注射抑制了两个品系的食物摄入量，同时体重减轻。奥斯本-孟德尔大鼠每天可耐受至少40单位的U-100精蛋白锌胰岛素并迅速增重，而每天给予超过2单位U-100精蛋白锌胰岛素的S 5B/Pl品系大鼠死亡。与饮用自来水的雌性奥斯本-孟德尔大鼠相比，饮用蔗糖溶液的大鼠积累了更多体脂，血清免疫反应性胰岛素水平更高，血清游离脂肪酸水平更低。用蔗糖溶液替代普通饮用水可抑制S 5B/Pl品系大鼠的体重增加。
