Bell D R, Woods R L, Levi J A, Fox R M, Tattersall M H
Aust N Z J Med. 1982 Jun;12(3):245-9. doi: 10.1111/j.1445-5994.1982.tb02469.x.
Thirty-seven patients with advanced ovarian cancer were treated in a prospective, randomised trial comparing chlorambucil with a combination of cyclophosphamide and cis-diamminedichloroplatinum (cis DDP). Treatment with the combination was associated with an increased overall response rate (69% versus 23%) (p = 0.04). A response was associated with a longer median survival but no survival advantage was demonstrated for patients who received cyclophosphamide/cis DDP. A larger study is needed to evaluate fully the potential of regimens containing cis DDP in the management of advanced ovarian cancer.
37例晚期卵巢癌患者参与了一项前瞻性随机试验，该试验比较了苯丁酸氮芥与环磷酰胺和顺二氯二氨铂（顺铂）联合用药的疗效。联合用药治疗的总体缓解率有所提高（69%对23%）（p = 0.04）。缓解与更长的中位生存期相关，但接受环磷酰胺/顺铂治疗的患者未显示出生存优势。需要开展更大规模的研究来全面评估含顺铂方案在晚期卵巢癌治疗中的潜力。
