Champlin R, Ho W, Arenson E, Gale R P
Blood. 1982 Oct;60(4):1038-41.
Eight patients with Ph1-positive chronic myelogenous leukemia (CML) in chronic or accelerated phase received high-dose cyclophosphamide, total body irradiation, and bone marrow transplantation from an HLA-identical sibling donor. All patients had prompt engraftment and achieved complete hematologic remission. Six patients remain alive and in continuous remission with a normal bone marrow karyotype 3-20+ mo posttransplant. One patient died from cytomegalovirus interstitial pneumonitis. Only one patient who was transplanted in accelerated phase relapsed 6.5 mo posttransplant and died in blast crisis. High-dose combined modality therapy is capable of producing sustained complete remissions in patients with CML treated during chronic or accelerated phase.
8例处于慢性期或加速期的Ph1阳性慢性粒细胞白血病（CML）患者接受了大剂量环磷酰胺、全身照射，并接受了来自 HLA 相同同胞供者的骨髓移植。所有患者均迅速植入并实现了完全血液学缓解。6例患者存活且持续缓解，移植后3 - 20+个月骨髓核型正常。1例患者死于巨细胞病毒性间质性肺炎。仅1例处于加速期移植的患者在移植后6.5个月复发并死于急变期。大剂量联合治疗方案能够使处于慢性期或加速期的CML患者获得持续的完全缓解。
