某些抗抑郁药物与脑内毒蕈碱型乙酰胆碱受体的结合。
The binding of some antidepressant drugs to brain muscarinic acetylcholine receptors.
作者信息
Golds P R, Przyslo F R, Strange P G
出版信息
Br J Pharmacol. 1980 Mar;68(3):541-9. doi: 10.1111/j.1476-5381.1980.tb14570.x.
Abstract
1 The binding of some antidepressant drugs, including some new drugs of atypical structure (flupenthixol, iprindole, maprotiline, mianserin, nomifensine, tofenacine and viloxazine) to muscarinic acetylcholine receptors in the brain has been studied by displacement of [3H]-atropine. 2 Many of the drugs are potent muscarinic antagonists. 3 Some correlation can be made between the affinity for binding to the muscarinic acetylcholine receptor and the incidence of anticholinergic side effects in clinical usage.
摘要
1 通过[3H] - 阿托品的置换作用，对包括一些非典型结构的新药（氟哌噻吨、茚满丙二胺、麦普替林、米安色林、诺米芬辛、托非那辛和维洛沙嗪）在内的某些抗抑郁药物与脑内毒蕈碱型乙酰胆碱受体的结合进行了研究。2 许多药物是强效毒蕈碱拮抗剂。3 在临床应用中，毒蕈碱型乙酰胆碱受体结合亲和力与抗胆碱能副作用发生率之间存在一定相关性。
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