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兔中对氨基苯胂酸毒性

Arsanilic acid toxicity in rabbits.

作者信息

Confer A W, Ward B C, Hines F A

出版信息

Lab Anim Sci. 1980 Apr;30(2 Pt 1):234-6.

PMID:7052379
Abstract

Rations from several rabbitries experiencing increased mortality, weight loss and diminished reproduction were analyzed for arsanilic acid. Levels of less than 56 ppm of arsanilic acid were found. A 30 day trial was conducted where arsanilic acid was given in doses of 1.6-16.2 mg/day in water to weanling and adult rabbits. The higher doses induced diarrhea, terminal convulsions and death. Weight loss or reduced weight gains occurred in six of seven treated groups. No significant gross or microscopic lesions were observed. Chemical analysis demonstrated the presence of increased total hepatic arsenic levels in treated compared to control rabbits.

摘要

对几个死亡率增加、体重减轻和繁殖力下降的兔场的饲料进行了对氨基苯胂酸分析。发现对氨基苯胂酸水平低于56 ppm。进行了一项为期30天的试验,以1.6 - 16.2毫克/天的剂量通过饮水给断奶幼兔和成年兔投喂对氨基苯胂酸。较高剂量导致腹泻、末期惊厥和死亡。七个处理组中有六个出现体重减轻或体重增加减少的情况。未观察到明显的大体或微观病变。化学分析表明,与对照兔相比,处理组兔肝脏中的总砷含量增加。

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