早期摘除眼球的负鼠同侧视网膜顶盖投射的可塑性：视网膜拓扑结构和放大因子的变化

Plasticity of the ipsilateral retinotectal projection in early enucleated opossums: changes in retinotopy and magnification factors.

作者信息

Lent R, Méndez-Otero R

出版信息

Neurosci Lett. 1980 May 15;18(1):37-43. doi: 10.1016/0304-3940(80)90210-4.

Abstract

The aberrant ipsilateral retinocollicular projection in early enucleated opossums was studied with both electrophysiological and radioautographic techniques. It was shown that the expanded projection originates from the same restricted region of temporal retina that gives origin to the normal ipsilateral projection. Furthermore, it was observed that the aberrant projection conveys a well-ordered retinotopy, with changes of the magnification factors compatible with the interpretation that ganglion cells at the borders of the ipsilaterally-projecting region display the most intense plastic response after enucleation.

摘要

采用电生理和放射自显影技术研究了早期摘除眼球的负鼠同侧视网膜-视丘投射异常情况。结果表明，扩大的投射起源于颞侧视网膜的同一受限区域，该区域也是正常同侧投射的起源部位。此外，观察到异常投射呈现出有序的视网膜拓扑结构，其放大因子的变化符合这样的解释：即同侧投射区域边界处的神经节细胞在眼球摘除后表现出最强烈的可塑性反应。