Shenkenberg T D, Rice L, Waddell C C
Arch Intern Med. 1982 Jan;142(1):153-4.
Karel Pelger described an abnormality of granulocyte nuclear segmentation in the context of advanced tuberculosis, but G. Huët questioned this association. It is now recognized that the Pelger-Huët nuclear anomaly (PHNA) can be either hereditary or acquired with systemic diseases, commonly hematologic dysplasias. An association with tuberculosis has never been well verified. The man described in our study had cachexia, high fevers, severe hypoproliferative anemia, and acquired PHNA. At autopsy, an overwhelming tuberculosis was discovered in the absence of any other underlying disease. Acquired PHNA may serve as a diagnostic and prognostic indicator in tuberculosis.
卡雷尔·佩尔格在晚期肺结核的背景下描述了粒细胞核分叶异常，但G. 于埃对这种关联提出了质疑。现在人们认识到，佩尔格-于埃核异常（PHNA）既可以是遗传性的，也可以是由全身性疾病（通常是血液系统发育异常）导致后天获得的。与肺结核的关联从未得到充分证实。我们研究中描述的这名男子患有恶病质、高热、严重的增殖低下性贫血，并患有后天性PHNA。尸检时，在没有任何其他基础疾病的情况下发现了严重的肺结核。后天性PHNA可能作为肺结核的诊断和预后指标。
