Sinha Y N, Gilligan T A
Endocrinology. 1982 Jan;110(1):126-30. doi: 10.1210/endo-110-1-126.
We investigated the effects of high doses of estrogen on the basal and stimulated secretion of PRL. Daily administration of 0.1 micrograms estradiol benzoate to female mice for 4 weeks significantly increased the amplitude of PRL release induced by perphenazine. A dose of 1.0 micrograms had no stimulatory effect, while doses of 10, 20, and 50 micrograms completely prevented the release of PRL in response to perphenazine. The rise in basal serum PRL concentrations seen at lower doses of estradiol benzoate was also minimized with 20- and 50-micrigrams doses. At the same time, PRL concentrations within the pituitary gland as well as pituitary weight consistently increased in response to all high doses of estradiol benzoate tested, although the increment at the highest dose (50 micrograms) was somewhat smaller. These results suggest that prolonged administration of estrogen in large amounts may be detrimental to the natural, acute release of PRL. We postulate that this effect may account, in part, for the observed mammostatic and antigalactic effects of high doses of estrogen.
我们研究了高剂量雌激素对催乳素基础分泌和刺激分泌的影响。对雌性小鼠每日给予0.1微克苯甲酸雌二醇，持续4周，可显著增加奋乃静诱导的催乳素释放幅度。1.0微克的剂量无刺激作用，而10、20和50微克的剂量则完全抑制了催乳素对奋乃静的释放反应。较低剂量苯甲酸雌二醇引起的基础血清催乳素浓度升高，在20微克和50微克剂量时也降至最低。同时，尽管最高剂量（50微克）时垂体催乳素浓度和垂体重量的增加幅度有所减小，但在所有测试的高剂量苯甲酸雌二醇作用下，垂体催乳素浓度和垂体重量均持续增加。这些结果表明，长期大量给予雌激素可能不利于催乳素的自然急性释放。我们推测，这种作用可能部分解释了高剂量雌激素所观察到的乳腺静止和抗泌乳作用。
