Rossouw J E, Labadarios D, Davis M, Williams R
S Afr Med J. 1978 Jul 29;54(5):183-6.
Biochemical deficiency of thiamine, vitamin B6, ascorbic acid or nicotinic acid occurred in 71% and 88% of patients with fulminant hepatic failure (FHF) and decompensated chronic liver disease (DCLD) respectively. Transient high plasma vitamin B6 concentrations in FHF were followed by low levels later in the illness. Although patients with DCLD of alcoholic aetiology tended to have lower circulating levels of vitamins than those with non-alcoholic DCLD, the prevalence of abnormally low concentrations did not differ. Decreased dietary nutrient intake and alcohol appeared to be less important determinants of biochemical vitamin deficiency than the presence of liver disease per se. Finally, urinary excretion of these vitamins or their major metabolites in patients with severe liver disease correlated poorly with circulating levels of vitamins.
暴发性肝衰竭（FHF）和失代偿性慢性肝病（DCLD）患者中，分别有71%和88%出现硫胺素、维生素B6、抗坏血酸或烟酸的生化缺乏。FHF患者血浆维生素B6浓度起初短暂升高，随后在病程后期降低。尽管酒精性病因的DCLD患者的维生素循环水平往往低于非酒精性DCLD患者，但异常低浓度的患病率并无差异。与肝病本身相比，饮食营养摄入减少和酒精似乎并非导致生化性维生素缺乏的重要决定因素。最后，重症肝病患者这些维生素或其主要代谢产物的尿排泄量与维生素循环水平的相关性较差。
