MacDonald V W, Charache S
Biochim Biophys Acta. 1982 Feb 4;701(1):39-44. doi: 10.1016/0167-4838(82)90309-0.
Analysis of optical absorption spectra of drug-hemoglobin reaction mixtures show that oxidation of oxyhemoglobins A, S and C by menadione and acetylphenylhydrazine and the consequent formation of methemoglobin, hemichromes and 'choleglobin' proceed at identical rates for all three hemoglobins. Nevertheless, precipitate formation, which is linked to hemichrome production, occurs in a definite order: S greater than C greater than A. Differences in precipitability among these three hemoglobins are linked to an as yet unidentified property of the aggregate hemichromes, which is not directly related to the rate of total hemichrome production.
对药物 - 血红蛋白反应混合物的光吸收光谱分析表明，甲萘醌和乙酰苯肼对血红蛋白A、S和C的氧化作用以及随后高铁血红蛋白、半色素和“胆绿蛋白”的形成，这三种血红蛋白的反应速率相同。然而，与半色素产生相关的沉淀形成呈现出一定的顺序：S大于C大于A。这三种血红蛋白在沉淀性上的差异与聚集半色素的一种尚未明确的特性有关，该特性与总半色素产生的速率并无直接关联。
