Stanfield B B, Cowan W M
Brain Res. 1982 Jan 28;232(1):162-70. doi: 10.1016/0006-8993(82)90619-9.
The projection of the septum to the dentate gyrus has been demonstrated autoradiographically and the pattern of acetylcholinesterase (AChE) staining in the dentate gyrus has been mapped histochemically, in a series of normal young adult rats and in a group of animals in which the entorhinal cortex had been ablated or its efferents to the dentate gyrus interrupted, some weeks earlier. It is clear from this material that the normal disposition of the septal projection to the dentate gyrus differs significantly from the pattern of AChE staining; however, in the denervated region of the molecular layer in the experimental animals there is a marked increase in the density of the septal projection which precisely coincides with the zone of intensification of AChE staining. It follows from this that although the distribution AChE does not accurately reflect the organization of the septo-dentate projection in normal animals, the intensification of AChE staining provides a good indication of the reorganization which occurs in this pathway following entorhinal deafferentation.
通过放射自显影已证实了中隔向齿状回的投射，并对一系列正常成年幼鼠以及一组在数周前切除了内嗅皮层或中断了其内嗅皮层至齿状回传出纤维的动物，进行了组织化学定位，描绘出了齿状回中乙酰胆碱酯酶（AChE）的染色模式。从这些材料可以清楚地看出，中隔向齿状回投射的正常分布与AChE染色模式有显著差异；然而，在实验动物分子层的去神经支配区域，中隔投射的密度显著增加，这与AChE染色增强的区域恰好重合。由此可知，虽然AChE的分布并不能准确反映正常动物中隔 - 齿状回投射的组织结构，但AChE染色增强为内嗅去传入后该通路中发生的重组提供了一个很好的指示。
