培养的神经胶质细胞上的毒蕈碱型乙酰胆碱受体。
Muscarinic acetylcholine receptors on culture glia cells.
作者信息
Repke H, Maderspach K
出版信息
Brain Res. 1982 Jan 28;232(1):206-11. doi: 10.1016/0006-8993(82)90627-8.
PMID:7055701
Abstract
Muscarinic acetylcholine receptors (76 fmol/mg protein) were detected on cultured glia cells (astroblasts) from embryonic chicken brain by specific [3H]quinuclidinylbenzilate (QNB) binding at physiological conditions. The QNB binding (Kd = 9.5 x 10(-11)) to the intact cells seems to be cooperative (nH = 1.98) as shown by graphical methods.
摘要
通过在生理条件下特异性的[3H]喹核醇基苯甲酸酯（QNB）结合，在来自胚胎鸡脑的培养神经胶质细胞（成星形细胞）上检测到毒蕈碱型乙酰胆碱受体（76 fmol/mg蛋白质）。如图示法所示，QNB与完整细胞的结合（Kd = 9.5×10⁻¹¹）似乎具有协同性（nH = 1.98）。
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