Battie C A, Verity M A
Brain Res. 1982 Feb;255(2):219-27. doi: 10.1016/0165-3806(82)90022-0.
Synaptosomal fractions isolated from the cerebrum of eu- and of hypothyroid rats during the neonatal period were analyzed by electron microscopy. This analysis revealed 3 main components: presynaptic endings, growth cones and unidentifiable structures that may be dendritic in origin. Since the size and the percentage of presynaptic endings were not altered by hypothyroidism but the size of the fraction in comparison to cerebrum weight was altered on postnatal day 14, it could be concluded that hypothyroidism results in a transient reduced synaptic density.
通过电子显微镜对新生期正常甲状腺和甲状腺功能减退大鼠大脑中分离出的突触体部分进行分析。该分析揭示了3个主要成分：突触前末梢、生长锥以及可能起源于树突的无法识别的结构。由于甲状腺功能减退并未改变突触前末梢的大小和百分比，但与大脑重量相比，该部分的大小在出生后第14天发生了变化，因此可以得出结论，甲状腺功能减退导致突触密度暂时降低。
