User P, Gottesmann C
Brain Res Bull. 1982 Jan;8(1):15-21. doi: 10.1016/0361-9230(82)90022-3.
The electrophysiological patterns of the frontal cortex and dorsal hippocampus were studied in the acute cerveau isolé rat. Central and peripheral stimulations were performed in order to modulate these patterns. The results showed that the permanent alternation of high amplitude spindle bursts and low voltage activity in the anterior neocortex of the acute cerveau isolé was influenced neither by olfactory nor by posterior hypothalamic stimulation. In contrast, these two kinds of stimulation easily modulated the continuous low frequency theta rhythm, recorded in the dorsal hippocampus, in terms of amplitude and in overall frequency. This modulation of the theta rhythm in the acute cerveau isolé rat mimics the changes observed when the normal rat comes from the intermediate stage of sleep (as characterized in the the acute intercollicular transected rat by high amplitude spindle bursts at frontal cortex level and low frequency theta activity in the dorsal hippocampus) to rapid sleep. These results further suggest that, during the intermediate stage (as in the cerveau isolé preparation), the hippocampus montonous theta activity appears through a brainstem disinhibitory process releasing the forebrain limbic pacemaker(s). During the following rapid sleep phase, the theta rhythm would be modulated by pontine activity influences acting on the theta generators.
在急性孤立脑大鼠中研究了额叶皮质和背侧海马体的电生理模式。进行了中枢和外周刺激以调节这些模式。结果表明，急性孤立脑大鼠前新皮质中高振幅纺锤体爆发和低电压活动的持续交替既不受嗅觉刺激也不受下丘脑后部刺激的影响。相反，这两种刺激很容易在振幅和整体频率方面调节背侧海马体中记录到的连续低频θ节律。急性孤立脑大鼠中θ节律的这种调节模拟了正常大鼠从中期睡眠阶段（如急性间脑横断大鼠中额叶皮质水平的高振幅纺锤体爆发和背侧海马体中的低频θ活动所表征）进入快速睡眠时观察到的变化。这些结果进一步表明，在中期阶段（如在孤立脑制备中），海马体单调的θ活动通过脑干去抑制过程出现，释放前脑边缘起搏器。在随后的快速睡眠阶段，θ节律将受到作用于θ发生器的脑桥活动影响的调节。
