Glashan R W, Riley A
Can J Surg. 1982 Jan;25(1):30-2.
The authors studied the effect of instilling Adriamycin intravesically in 21 patients with urothelial dysplasia and early carcinoma in situ. The effectiveness of the treatment was assessed by repeated urine cytology, cystoscopy and repeated biopsy of the bladder mucosa. No serious side effects were noted. Adriamycin causes the death of malignant cells, general improvement in the appearance of the bladder mucosa at cystoscopy and histologic evidence of endothelial damage to the bladder mucosa. The cytologic changes continue for many months after treatment.
作者研究了对21例膀胱上皮发育异常和早期原位癌患者进行膀胱内灌注阿霉素的效果。通过重复尿液细胞学检查、膀胱镜检查以及对膀胱黏膜进行重复活检来评估治疗效果。未观察到严重副作用。阿霉素可导致恶性细胞死亡，膀胱镜检查时膀胱黏膜外观总体改善，且有膀胱黏膜内皮损伤的组织学证据。治疗后细胞学变化会持续数月。
