Munz D L, Altmeyer P, Holzmann H, Encke A, Hör G
Dtsch Med Wochenschr. 1982 Jan 22;107(3):86-91. doi: 10.1055/s-2008-1069877.
Lymphoscintigraphy was performed pre- or postoperatively in 42 patients with malignant melanoma of the skin. The test consisted of the injection of 1.5-2.0 mCi 99mTc-labelled antimony sulphide colloid, both intracutaneously and subcutaneously, either around the primary tumour or along its edges or into the centre of the excision scar or contralaterally. The draining lymph-node groups were scanned with a gamma-camera 4-6 hours after the injection. Except for one patient, the radioactive tracer had always disappeared from the injection site and had accumulated in th regional lymph-nodes. In 11 of 28 patients with melanoma on the trunk, lymphatic drainage was to more than one regional lymph-node group. In most cases with cutaneous melanoma on the trunk, lymphatic drainage could not be anatomically predicted, but easily and unequivocally identified by lymphoscintigraphy. On the other hand, lymphatic drainage of a melanoma of the head or neck, as well as of distal segments of the limbs, almost always followed anatomical expectations. Using lymphoscintigraphic findings, prophylactic lymphadenectomy could be performed selectively in "high risk" melanomas.
对42例皮肤恶性黑色素瘤患者在术前或术后进行了淋巴闪烁造影。该检查包括在原发肿瘤周围、边缘、切除瘢痕中心或对侧皮内和皮下注射1.5 - 2.0毫居里的99mTc标记硫化锑胶体。注射后4 - 6小时用γ相机扫描引流淋巴结群。除1例患者外,放射性示踪剂总是从注射部位消失并在区域淋巴结中聚集。在28例躯干黑色素瘤患者中,有11例的淋巴引流至一个以上区域淋巴结群。在大多数躯干皮肤黑色素瘤病例中,淋巴引流无法从解剖学上预测,但通过淋巴闪烁造影可轻松明确识别。另一方面,头颈部黑色素瘤以及四肢远端节段的淋巴引流几乎总是符合解剖学预期。根据淋巴闪烁造影结果,可对“高危”黑色素瘤选择性地进行预防性淋巴结清扫术。