Fukushima K, Ohno M, Takahashi K, Kato M
Exp Brain Res. 1982;45(1-2):303-12. doi: 10.1007/BF00235791.
Experiments were performed on cats anesthetized with alpha chloralose to locate neurons in and around the interstitial nucleus of Cajal (INC) that project to the vestibular nuclei, and to study labyrinthine inputs to these neurons. Neurons that project to the vestibular nuclei were identified by microstimulation confined to the vestibular nuclei on both sides. All neurons thus identified were activated antidromically from the ipsilateral (but not contralateral) vestibular nuclei. Vestibular projecting neurons were found in the INC and the reticular formation rostral, dorsal and caudal to the INC. About 23% of these neurons were vestibular branching spinal projecting neurons. The median conduction velocity of vestibular projecting neurons was estimated to be in the neighborhood of 12-16 m/s. Stimulation of the contralateral vestibular nerve evoked firing in 29% of neurons projecting to the vestibular nuclei, but not to the spinal cord. Interstitial neurons responded more frequently than reticular neurons (45% vs 11% chi 2 test, p less than 0.001). By stimulation of individual semicircular canal nerves, it was shown that vestibular projecting neurons receive excitation from the contralateral vertical canals, but do not receive substantial inputs from the horizontal canal. Stimulation of the ipsilateral vestibular nerve excited 10% of neurons; suppression of activity was observed for six cells and four of the six were excited by stimulation of the contralateral vestibular nerve. Stimulation of ipsilateral individual semicircular canal nerve did not excite any cells tested; the activity of a few cells was suppressed by stimulation of the vertical canal nerves. One neuron received excitation from the contralateral anterior canal and suppression from the ipsilateral posterior canal. Vestibular branching spinal projecting neurons rarely received labyrinthine inputs as already reported (Fukushima et al. 1980a). These results suggested that vestibular projecting neurons may be involved in vertical vestibular reflexes.U
实验在使用α-氯醛糖麻醉的猫身上进行，以定位 Cajal 间质核（INC）及其周围投射到前庭核的神经元，并研究这些神经元的迷路传入。通过局限于双侧前庭核的微刺激来识别投射到前庭核的神经元。所有如此识别出的神经元均从前庭核的同侧（而非对侧）被逆向激活。在前庭核以及 INC 前方、背侧和尾侧的网状结构中发现了前庭投射神经元。这些神经元中约23%是前庭分支脊髓投射神经元。前庭投射神经元的中位传导速度估计在12 - 16米/秒左右。刺激对侧前庭神经可使29%投射到前庭核但不投射到脊髓的神经元产生放电。间质神经元的反应比网状神经元更频繁（卡方检验，45%对11%，p小于0.001）。通过刺激单个半规管神经表明，前庭投射神经元接受来自对侧垂直半规管的兴奋，但不接受来自水平半规管的大量传入。刺激同侧前庭神经可使10%的神经元兴奋；观察到6个细胞的活动受到抑制，其中4个在刺激对侧前庭神经时兴奋。刺激同侧单个半规管神经未使任何测试细胞兴奋；垂直半规管神经的刺激抑制了少数细胞的活动。一个神经元接受来自对侧前半规管的兴奋和来自同侧后半规管的抑制。如先前报道（Fukushima 等人，1980a），前庭分支脊髓投射神经元很少接受迷路传入。这些结果表明前庭投射神经元可能参与垂直前庭反射。
