Hollister L E
J Clin Psychiatry. 1982 Feb;43(2):66-9.
Plasma concentrations of four tricyclic antidepressant drugs were monitored in 180 patients. Plasma concentrations incongruent with dose suggested noncompliance at some time among 20% of the patients. Plasma concentrations correlated poorly with dose except with amitriptyline. Plasma concentration of drug and active metabolite, in the case of imipramine and amitriptyline, tended to be higher in ng/ml than the daily dose in mg; the converse was true for nortriptyline and desipramine. Most patients achieved "therapeutic"plasma concentrations at doses of 150 mg/day. However, "therapeutic" plasma concentrations did not correlate well with clinical response.
对180名患者的四种三环类抗抑郁药物的血浆浓度进行了监测。血浆浓度与剂量不一致表明20%的患者在某些时候未遵医嘱服药。除阿米替林外，血浆浓度与剂量的相关性较差。对于丙咪嗪和阿米替林，药物及其活性代谢物的血浆浓度以纳克/毫升计往往高于每日剂量以毫克计；去甲替林和地昔帕明则相反。大多数患者在每日剂量为150毫克时达到“治疗性”血浆浓度。然而，“治疗性”血浆浓度与临床反应的相关性不佳。
