Höfinger E, Le Quesne P M, Gajree T
J Neurol Sci. 1982 Feb;53(2):159-67. doi: 10.1016/0022-510x(82)90002-8.
Serial measurements of maximal motor nerve conduction velocity and muscle action potential amplitude were made on 2 groups of rats for up to 16 months. Group A received 0.05% IDPN in drinking water. Group B received a single injection of 1 g/kg i.p. In the chronically intoxicated animals conduction velocity progressively fell compared with control animals, from a reduction of 7% after 4 months to 22% after 13 months. There was no reduction in muscle action potential amplitude. Marked axonal atrophy was found in distal ventral roots. Many grossly dilated axons were present in proximal ventral roots. In the animals which received a single dose of IDPN no electrophysiological changes were found. A few dilated axons were present in proximal ventral roots, but changes were less severe than in Group A. No distal axonal atrophy was demonstrated.
对两组大鼠进行了长达16个月的最大运动神经传导速度和肌肉动作电位幅度的系列测量。A组在饮用水中给予0.05%的IDPN。B组腹腔注射1 g/kg的单次剂量。与对照动物相比，慢性中毒动物的传导速度逐渐下降，从4个月后的7%下降到13个月后的22%。肌肉动作电位幅度没有降低。在远端腹根发现明显的轴突萎缩。近端腹根有许多明显扩张的轴突。在接受单次剂量IDPN的动物中未发现电生理变化。近端腹根有一些扩张的轴突，但变化不如A组严重。未显示远端轴突萎缩。
