Suber R L, Gudat J C, Edds G T
J Pharm Sci. 1982 Jan;71(1):70-3. doi: 10.1002/jps.2600710118.
Administration of sulfonamides during periods of hepatobiliary failure or hepatic immaturity increases the toxic potential of unconjugated or indirect bilirubin. A small but statistically significant increase of indirect, or unconjugated bilirubin was noted in dogs after oral administration of sulfisoxazole (100 mg/kg). A similar increase was not observed in swine after oral or intravenous administration of sulfisoxazole (100 mg/kg) or in humans (approximately 28 mg/kg) after oral administration or in dogs (100 mg/kg) after intravenous administration. Total and conjugated bilirubin showed small but statistically significant increases and were significantly correlated in dogs after oral and intravenous administration of sulfisoxazole (100 mg/kg) and in swine after oral administration of sulfisoxazole (100 mg/kg). There was a significant negative correlation between conjugated and indirect bilirubin, while total bilirubin increased in dogs after oral and intravenous administration of sulfisoxazole. These data illustrate a difference in species and administration route when attempting to assess the potential toxicity of bilirubin.
在肝胆功能衰竭或肝脏未成熟期间给予磺胺类药物会增加未结合胆红素或间接胆红素的毒性潜力。口服磺胺异恶唑（100毫克/千克）后，犬的间接胆红素或未结合胆红素出现了虽小但具有统计学意义的升高。口服或静脉注射磺胺异恶唑（100毫克/千克）后，猪未出现类似升高；口服后，人类（约28毫克/千克）未出现类似升高；静脉注射后，犬（100毫克/千克）也未出现类似升高。口服和静脉注射磺胺异恶唑（100毫克/千克）后，犬的总胆红素和结合胆红素虽有小幅但具有统计学意义的升高，且二者显著相关；口服磺胺异恶唑（100毫克/千克）后，猪的总胆红素和结合胆红素也有类似情况。结合胆红素与间接胆红素之间存在显著负相关，而口服和静脉注射磺胺异恶唑后，犬的总胆红素升高。这些数据表明，在评估胆红素潜在毒性时，不同物种和给药途径存在差异。
