Nwoye L O, Goldspink G
Muscle Nerve. 1982 Jan;5(1):69-72. doi: 10.1002/mus.880050113.
The amount of phosphoryl creatine (PC) hydrolysed during a ten-second isometric contraction was measured in the biceps brachii (fast) and soleus (slow) muscles of adult normal and dystrophic mice (Re 129 strain) following inhibition of glycolysis and oxidative phosphorylation. The dystrophic muscles were found to have a lower isometric economy (tension-time integral per mumol PC) than the normal muscles. This was particularly so in the case of the fast biceps brachii muscle which is affected by dystrophy to a greater extent than the slow soleus muscle. The isometric economy of the dystrophic muscles was lower even when the results were based on a total creatine rather than on a weight basis. This suggests there may be some defect in the contractile proteins of dystrophic muscle. The normal soleus muscle was found to be approximately three times more economical in maintaining tension than the normal biceps brachii muscle. This indicates the adaptation of slow muscles such as the soleus are used for maintenance of posture.
在抑制糖酵解和氧化磷酸化后，测量了成年正常小鼠和营养不良小鼠（Re 129品系）肱二头肌（快肌）和比目鱼肌（慢肌）在10秒等长收缩过程中水解的磷酸肌酸（PC）量。发现营养不良的肌肉比正常肌肉具有更低的等长收缩效率（每微摩尔PC的张力-时间积分）。在快速的肱二头肌中尤其如此，它比慢速的比目鱼肌受营养不良的影响更大。即使结果是基于总肌酸而不是基于重量，营养不良肌肉的等长收缩效率也较低。这表明营养不良肌肉的收缩蛋白可能存在一些缺陷。发现正常的比目鱼肌在维持张力方面比正常的肱二头肌经济约三倍。这表明像比目鱼肌这样的慢肌适应于维持姿势。
