Shinohara Y, Gotoh F, Takagi S
Stroke. 1978 Sep-Oct;9(5):504-8. doi: 10.1161/01.str.9.5.504.
Cerebrovascular autoregulation and CO2 reactivity were measured repeatedly in 3 patients with the multiple system atrophy type of autonomic insufficiency (Shy-Drager syndrome) by means of the 133Xe injection method. The degree of cerebral blood flow (CBF) dysautoregulation showed day-to-day variations in 2 of the 3 patients. The CO2 reactivity was normal or supernormal in the supine position in patients with impaired autoregulation. In the head-up position the response to CO2 was slightly suppressed in 2 of the patients, suggesting that chemical control may have tended to compensate for CBF dysautoregulation. It is concluded that the mechanism of chemical control of the cerebrovasculature is different from that which controls autoregulation and may have partially compensated for CBF dysautoregulation.
采用133Xe注入法，对3例患有自主神经功能不全的多系统萎缩型（夏伊-德雷格综合征）患者反复测量脑血管自动调节和二氧化碳反应性。3例患者中有2例的脑血流量（CBF）调节异常程度呈现出每日变化。在自动调节受损的患者中，仰卧位时二氧化碳反应性正常或超常。在头高位时，2例患者对二氧化碳的反应略有抑制，这表明化学调节可能倾向于补偿CBF调节异常。得出的结论是，脑血管系统的化学调节机制与控制自动调节的机制不同，可能部分补偿了CBF调节异常。
