Brown G W, Saunders J P, Singh S, Huxsoll D L, Shirai A
Trans R Soc Trop Med Hyg. 1978;72(4):412-6. doi: 10.1016/0035-9203(78)90138-4.
A single dose of 200 mg of doxycycline was shown to be as effective as a seven day course of tetracycline, in patients suspected of having scrub typhus. 65 (44%) of the 149 patients studied fulfilled the criteria for definite diagnosis of scrub typhus; 10 had an additional diagnosis. Rickettsia tsutsugamushi was isolated from 49 (75%) patients. There was no difference between the two treatment groups in time to defervescence, abolition of cough and headache, or in the time taken to recover well-being. There were no relapses in either group. Of the remaining 84 patients, a causal diagnosis was achieved in 52. Irrespective of a diagnosis there was no difference in apparent response to either doxycycline or tetracycline.
对于疑似恙虫病的患者，单剂量200毫克强力霉素被证明与为期七天的四环素疗程效果相同。在149名接受研究的患者中，65名（44%）符合恙虫病确诊标准；10名有额外诊断。从49名（75%）患者中分离出恙虫病东方体。两个治疗组在退热时间、咳嗽和头痛消失时间或恢复健康所需时间方面没有差异。两组均无复发情况。在其余84名患者中，52名做出了病因诊断。无论诊断如何，强力霉素或四环素的明显反应均无差异。
