Hoffman D A, McConahey W M, Diamond E L, Kurland L T
Am J Epidemiol. 1982 Feb;115(2):243-54. doi: 10.1093/oxfordjournals.aje.a113296.
To evaluate the late effects of exposure to radioiodine (131I), a retrospective cohort study was conducted of women treated for hyperthyroidism at the Mayo Clinic, Rochester, Minnesota, from 1946 through 1964. Cause of death was determined in 1005 women treated with 131I and in 2141 women surgically treated. No increased risk of total mortality was observed for the 131I-treated women (relative risk = 1.0). There were no increased risks for the major causes of mortality (cancer, cardiovascular-renal disease or cerebrovascular lesions) in the 131I-treated women; in addition, there were no increased risks for site-specific cancer mortality. Several hypotheses are presented to suggest reasons for the lack of an association between 131I exposure and increased cancer mortality.
为评估放射性碘（131I）暴露的远期影响，对1946年至1964年在明尼苏达州罗切斯特市梅奥诊所接受甲状腺功能亢进治疗的女性进行了一项回顾性队列研究。确定了1005名接受131I治疗的女性和2141名接受手术治疗的女性的死亡原因。接受131I治疗的女性未观察到总死亡率增加（相对风险=1.0）。接受131I治疗的女性主要死因（癌症、心血管-肾脏疾病或脑血管病变）未增加风险；此外，特定部位癌症死亡率也未增加风险。提出了几种假设，以说明131I暴露与癌症死亡率增加之间缺乏关联的原因。
