Baloh R W, Dietz J, Spooner J W
Ann Neurol. 1982 Jan;11(1):95-7. doi: 10.1002/ana.410110117.
A patient with chronic manic-depressive illness developed generalized myoclonus and spontaneous ocular oscillations after a single 2 gm dose of L-tryptophan. She had been pretreated with both a tricyclic antidepressant and a monoamine oxidase inhibitor. The involuntary movements gradually disappeared within 24 hours after the drugs were discontinued. Electrooculographic recording 7 hours after onset of the abnormal eye movements revealed square-wave jerks and hypometric voluntary saccades. Pursuit as well as optokinetic and vestibular slow phases were normal except for superimposition of the square-wave jerks. Repeat recording 24 hours later was entirely normal.
一名患有慢性躁郁症的患者在单次服用2克L-色氨酸后出现了全身性肌阵挛和自发性眼球震颤。她之前同时接受过三环类抗抑郁药和单胺氧化酶抑制剂的治疗。在停药后24小时内，这些不自主运动逐渐消失。在异常眼球运动开始7小时后进行的眼电图记录显示出方波急跳和低幅随意性扫视。除了方波急跳的叠加外，跟踪以及视动和前庭慢相均正常。24小时后的重复记录完全正常。
