Wilkin J K, Rountree C B
Arch Dermatol. 1982 Feb;118(2):109-11.
A patient with the carcinoid syndrome had flushes provoked by the ingestion of water at 60 degrees C, red wine, and milk chocolate. The patient was given sequential courses of clonidine hydrochloride, chlorpheniramine maleate, cimetidine, and a combination of chlorpheniramine and cimetidine. No flushes followed ingestion of red wine or milk chocolate during treatment courses with cimetidine (alone or in combination with chlorpheniramine) or clonidine. Chlorpheniramine alone did not affect flushing. None of the pharmacologic agents altered the flushing response to the ingestion of water at 60 degrees C.
一名患有类癌综合征的患者在摄入60摄氏度的水、红酒和牛奶巧克力后会出现潮红。该患者先后接受了盐酸可乐定、马来酸氯苯那敏、西咪替丁以及氯苯那敏和西咪替丁联合用药的治疗疗程。在使用西咪替丁（单独或与氯苯那敏联合使用）或可乐定的治疗疗程中，摄入红酒或牛奶巧克力后未出现潮红。单独使用氯苯那敏对潮红无影响。没有一种药物能改变对摄入60摄氏度水的潮红反应。
