精神分裂症患者和正常人尿中3,4-二甲氧基苯乙胺排泄及代谢的定量研究。

Quantitative investigation on the urinary excretion and metabolism of 3,4-dimethoxyphenylethylamine in schizophrenics and normal individuals.

作者信息

Hempel K, Ullrich H, Philippu G

出版信息

Biol Psychiatry. 1982 Jan;17(1):49-59.

Abstract

A quantitative method for the detection of DMPEA in urine was developed. It is based on the fluorometric determination of DMPEA in the form of its phosphopyridoxyl derivate. The limit of detection is 2 microgram DMPEA per 1 g creatinine. The DMPEA content was measured in urine from healthy persons, from schizophrenics, and from psychiatric patients without schizophrenia hospitalized with the schizophrenics. From each person five to ten 24-hr urine samples were investigated. DMPEA could be found neither in schizophrenics nor in controls or healthy persons. Finally, the urinary excretion of parenterally applied 14C-DMPEA was determined in three healthy volunteers and in three rats. In man about 25% of the label was excreted as DMPEA. The main metabolite in urine was homoveratric acid. Both compounds were excreted as conjugates.

摘要

开发了一种检测尿液中DMPEA的定量方法。它基于以磷酸吡哆醛衍生物形式对DMPEA进行荧光测定。检测限为每1g肌酐中2微克DMPEA。测定了健康人、精神分裂症患者以及与精神分裂症患者一起住院的无精神分裂症的精神病患者尿液中的DMPEA含量。对每个人的五到十个24小时尿液样本进行了研究。在精神分裂症患者、对照组或健康人中均未发现DMPEA。最后，在三名健康志愿者和三只大鼠中测定了经肠胃外给予的14C-DMPEA的尿排泄情况。在人体中，约25%的标记物以DMPEA形式排泄。尿液中的主要代谢产物是高藜芦酸。这两种化合物均以共轭物形式排泄。