Panasci L, Polizzi G, Palmer S
Cancer Lett. 1982 Jan;15(1):81-6. doi: 10.1016/0304-3835(82)90079-9.
Cycloheximide at 100 mg/kg administered intraperitoneally to P388 tumor-bearing CD2F1 mice diminished protein synthesis in the liver, spleen, kidneys, lungs, small intestine and P388 tumor 75 min after administration. Six hours after administration all the above tissues except the tumor no longer demonstrated suppression of protein synthesis. The lethal toxicity of single intraperitoneal doses of methotrexate administered at 1, 3 or 6 h after the cycloheximide was diminished. However, no increase in therapeutic index was achieved with this dose schedule in P388 tumor bearing CD2F1 mice.
对携带P388肿瘤的CD2F1小鼠腹腔注射100mg/kg放线菌酮后75分钟，肝脏、脾脏、肾脏、肺、小肠和P388肿瘤中的蛋白质合成减少。给药6小时后，除肿瘤外，上述所有组织均不再表现出蛋白质合成受抑制。在放线菌酮给药后1、3或6小时腹腔注射单剂量甲氨蝶呤，其致死毒性降低。然而，在携带P388肿瘤的CD2F1小鼠中，这种给药方案并未提高治疗指数。
