阿霉素诱导的体外脂质过氧化的进一步研究。

Further studies on adriamycin induced in vitro lipid peroxidation.

作者信息

Facchinetti T, Müh-Zange M, Salmona M, Carini M, Remmer H

出版信息

Chem Biol Interact. 1982 Feb;38(3):357-67. doi: 10.1016/0009-2797(82)90065-5.

Abstract

Adriamycin (AM)-induced lipid peroxidation was studied in rat liver microsomal system, measuring colour produced by thiobarbituric acid (TBA) reactive material and the development of volatile hydrocarbons. The onset of this degradative process is closely related to the AM content. This phenomenon appears to be highly influenced by the buffer used for the microsomal preparation. The effect of AM on FE--ADP-induced lipid peroxidation in liver microsomes has also been studied.

摘要

在大鼠肝微粒体系统中研究了阿霉素（AM）诱导的脂质过氧化作用，通过测量硫代巴比妥酸（TBA）反应性物质产生的颜色以及挥发性碳氢化合物的生成情况来进行研究。这种降解过程的起始与AM含量密切相关。该现象似乎受用于微粒体制备的缓冲液的影响很大。还研究了AM对肝微粒体中FE-ADP诱导的脂质过氧化作用的影响。