Holtz K, Feller A M, Seybold-Epting W
Dtsch Med Wochenschr. 1982 Apr 2;107(13):494-7. doi: 10.1055/s-2008-1069962.
Valve thromboses were observed in nine patients, seven females and two males, aged 46 years on average, between 1/2 and 5 1/2 years after replacement of a mitral valve (n = 6) or an aortic valve (n = 3) by a tilting disc valve (Björk-Shiley, n = 6; Lillehei-Kaster n = 3). In eight cases reoperation was necessary, mainly as an emergency. One patient died preoperatively, five died intra- or postoperatively. Besides the adequate valve type, prophylaxis of valve thrombosis by conscientious anticoagulation is the most important measure. Should leading symptoms - disappearance of valve click and increasing cardiac insufficiency during irregular anticoagulation - occur, immediate referral to cardiac surgery is required.
在9例患者中观察到瓣膜血栓形成，其中7例女性，2例男性，平均年龄46岁，在二尖瓣（n = 6）或主动脉瓣（n = 3）被倾斜碟瓣（Björk-Shiley，n = 6；Lillehei-Kaster，n = 3）置换后的1.5至5.5年之间。8例需要再次手术，主要是作为急诊。1例患者术前死亡，5例在术中或术后死亡。除了选择合适的瓣膜类型外，通过认真抗凝预防瓣膜血栓形成是最重要的措施。如果出现主要症状——瓣膜喀喇音消失以及在不规则抗凝期间心脏功能不全加重——应立即转诊至心脏外科。
