苯巴比妥和印防己毒素对大鼠特定脑区胆碱乙酰转移酶活性的比较作用。

Comparative effects of phenobarbital and picrotoxin on the choline acetyltransferase activity of specific rat brain areas.

Owasoyo J O

Gen Pharmacol. 1982;13(1):71-3. doi: 10.1016/0306-3623(82)90016-7.

Abstract

The Choline acetyltransferase (ChAT) activity of rat cerebral cortex, cerebellum, hippocampus, hypothalamus midbrain, pons, medulla oblongata and caudate nucleus was determined in control, phenobarbital-treated and picrotoxin-treated animals. 2. Phenobarbital increased ChAT activity in the cerebral cortex an caudate nucleus only. 3. Picrotoxin increased ChAT activity in the cerebellum and caudate nucleus. 4. These findings further clarify the effects of CNS depressants and stimulants on rodent brain cholinergic system.

摘要

在对照组、苯巴比妥处理组和印防己毒素处理组的动物中，测定了大鼠大脑皮层、小脑、海马、下丘脑、中脑、脑桥、延髓和尾状核的胆碱乙酰转移酶（ChAT）活性。2. 苯巴比妥仅增加了大脑皮层和尾状核中的ChAT活性。3. 印防己毒素增加了小脑中的ChAT活性。4. 这些发现进一步阐明了中枢神经系统抑制剂和兴奋剂对啮齿动物脑胆碱能系统的影响。