Boll M, Brückner E, Berndt J
Hoppe Seylers Z Physiol Chem. 1982 Jan;363(1):103-6. doi: 10.1515/bchm2.1982.363.1.103.
The activity of lipogenic enzymes in rat liver decreases during fasting and is increased on subsequent refeeding. There are considerable age-related differences in the activities of the lipogenic enzymes on dietary manipulation. On refeeding starved animals with either a standard diet or with a high-sucrose, fat-free diet, the increase of the activities was much greater in young animals than in old ones. Old animals exhibited a hyperlipoproteinemia and the activities of their lipogenic enzymes were decreased. The present results, together with reports in the literature, make it likely that the diminished activity of lipogenesis in old animals is a function of adipositas rather than of age.
大鼠肝脏中脂肪生成酶的活性在禁食期间降低，而在随后重新进食时升高。在饮食调控下，脂肪生成酶的活性存在显著的年龄相关差异。用标准饮食或高蔗糖无脂饮食重新喂养饥饿动物时，幼龄动物脂肪生成酶活性的增加比老龄动物大得多。老龄动物表现出高脂蛋白血症，其脂肪生成酶的活性降低。目前的结果以及文献中的报道表明，老龄动物脂肪生成活性降低可能是肥胖的作用，而非年龄的作用。
