Castro M, Descamps R, Thomis J A
Int J Clin Pharmacol Ther Toxicol. 1982 Feb;20(2):88-91.
The long-term electrocardiographic effects of sotalol, a beta blocker tha prolongs the cardiac repolarization time in animals, were investigated in ten hypertensive patients and compared to ten matched hypertensive patients treated with diuretics. An electrocardiogram was recorded before and during an exercise test on a bicycle. Heart rate was lower at rest and throughout exercise in the sotalol-treated patients. The PR and QT intervals of the ECG were significantly longer at rest and after exercise in the sotalol group, whereas QRS widths were similar in both groups. The QTC interval in the sotalol group was 0.41 +/- 0.02 s and 0.47 +/- 0.01 s, at rest and after exercise, respectively, which was not significantly different from 0.42 +/- 0.01 s and 0.43 +/- 0.02 s, respectively, in the diuretic group. These findings were discussed in relation to observations made with other beta blockers.
索他洛尔是一种能延长动物心脏复极时间的β受体阻滞剂，本研究调查了10例高血压患者服用索他洛尔后的长期心电图效应，并与10例服用利尿剂的匹配高血压患者进行了比较。在自行车运动试验前后记录心电图。服用索他洛尔的患者在静息时和整个运动过程中心率较低。索他洛尔组静息时和运动后的心电图PR间期和QT间期显著延长，而两组的QRS宽度相似。索他洛尔组静息时和运动后的QTC间期分别为0.41±0.02秒和0.47±0.01秒，与利尿剂组分别为0.42±0.01秒和0.43±0.02秒相比，差异无统计学意义。结合其他β受体阻滞剂的观察结果对这些发现进行了讨论。
