Fulton A B, Manning K A, Baker B N, Schukar S E, Bailey C J
Invest Ophthalmol Vis Sci. 1982 Mar;22(3):386-93.
Adaptation to steady background lights has been investigated in pcd/pcd mice, a mutant strain with retinal degeneration. The hyperbolic stimulus/response functions of the scotopic b-wave of the electroretinogram show progressive changes. For the dark-adapted eyes the decrease in log sensitivity between ages 1 and 12 months is related linearly to the decreasing rhodopsin content. The observed decline in amplitude of maximum responses from dark-adapted eyes begins only after age 5 months and is accompanied by gradual prolongation of the time to the peak of half-maximum b-wave responses. At all ages, the sensitivity of response is changed little by increments of steady red background lights; the greatest slope of log sensitivity vs. log background plots is about +0.2. (In normal mice the slope is about +0.9.) The pcd/pcd b-wave results do not fit the normal empirical relation that is thought to reflect neural processing in the distal retina. Thus the present results suggest that neural processing is abnormal in pcd/pcd retinas.
对患有视网膜变性的突变品系pcd/pcd小鼠适应稳定背景光的情况进行了研究。视网膜电图暗视b波的双曲线刺激/反应函数呈现出渐进性变化。对于暗适应的眼睛，1至12月龄之间对数敏感度的降低与视紫红质含量的减少呈线性相关。观察到暗适应眼睛最大反应幅度的下降仅在5月龄后开始，并伴随着半最大b波反应峰值时间的逐渐延长。在所有年龄段，稳定红色背景光的增加对反应敏感度的影响很小；对数敏感度与对数背景图的最大斜率约为+0.2。（正常小鼠中的斜率约为+0.9。）pcd/pcd小鼠的b波结果不符合被认为反映远端视网膜神经处理的正常经验关系。因此，目前的结果表明pcd/pcd视网膜中的神经处理是异常的。
