最大呼气流量与小气道尺寸及病理状况的相关性。

Correlations of maximum expiratory flow with small airway dimensions and pathology.

作者信息

Berend N, Thurlbeck W M

出版信息

J Appl Physiol Respir Environ Exerc Physiol. 1982 Feb;52(2):346-51. doi: 10.1152/jappl.1982.52.2.346.

DOI:10.1152/jappl.1982.52.2.346

Abstract

Pressure-volume and maximum expiratory flow-volume curves with air and a He-O2 mixture were performed in 25 excised human lungs. Small airway dimensions were measured, and the degree of various small airway lesions and emphysema was graded. Correlations were then made between the maximum flow (Vmax) at a transpulmonary pressure (PL) of 5 cmH2O and these measurements and scores. Small airway dimensions correlated poorly with Vmax. However, significant correlations were obtained between Vmax and the inflammation score (P less than 0.05), fibrosis score (P less than 0.05), and emphysema grade (P less than 0.01) but not smooth muscle hyperplasia or pigmentation. Neither the increase in flow with He-O2 nor the volume of flow correlated significantly with any small airway measurement or score.

摘要

对25个离体人肺进行了空气和氦氧混合气的压力-容积及最大呼气流量-容积曲线测定。测量了小气道尺寸，并对各种小气道病变和肺气肿的程度进行了分级。然后对跨肺压（PL）为5 cmH₂O时的最大流量（Vmax）与这些测量值及评分进行相关性分析。小气道尺寸与Vmax的相关性较差。然而，Vmax与炎症评分（P<0.05）、纤维化评分（P<0.05）和肺气肿分级（P<0.01）之间存在显著相关性，但与平滑肌增生或色素沉着无关。氦氧混合气使流量增加的幅度及流量容积均与任何小气道测量值或评分无显著相关性。