Sprincl L, Kusková M, Roda J, Králícek J
J Biomed Mater Res. 1982 Mar;16(2):95-104. doi: 10.1002/jbm.820160202.
The biological compatibility of polypyrrolidone was investigated using subcutaneous implantation in rats. Acute (10 days) and chronic (360 days after implantation) tissue reaction was characterized numerically and compared with poly(2-hydroxyethyl methacrylate), used in the Drug Control Research Institute in Prague as a standard in the evaluation of polymers, for which good tolerance in the clinical practice has been demonstrated. Surface changes in the polymer were evaluated by using a scanning electron microscope.
通过在大鼠皮下植入来研究聚吡咯烷酮的生物相容性。对急性（10天）和慢性（植入后360天）组织反应进行数值表征，并与布拉格药物控制研究所用作聚合物评估标准的聚（甲基丙烯酸2-羟乙酯）进行比较，该聚合物在临床实践中已证明具有良好的耐受性。使用扫描电子显微镜评估聚合物的表面变化。
