Ejzemberg R, Borsos T
J Immunol. 1982 Apr;128(4):1600-2.
The hemolytic efficiency of rabbit-anti-Forssman IgM antibody depends on the source of complement components. With whole guinea pig complement as few as one in 10 IgM molecules was hemolytic; it was found that with purified guinea pig C1, C4, and C2 components and with rat late-acting components, all IgM molecules were hemolytic. Evidence indicates that the block occurred as a result of generating at least two different cell-bound C4 molecules, one of which was not competent with homologous late-acting components.
兔抗福斯曼IgM抗体的溶血效率取决于补体成分的来源。使用全豚鼠补体时，每10个IgM分子中只有1个具有溶血活性；研究发现，使用纯化的豚鼠C1、C4和C2成分以及大鼠后期作用成分时，所有IgM分子都具有溶血活性。有证据表明，这种阻断是由于产生了至少两种不同的细胞结合C4分子而导致的，其中一种与同源后期作用成分不兼容。
