Kawada K
Nihon Sanka Fujinka Gakkai Zasshi. 1982 Jan;34(1):75-82.
The purpose for this experiment is to know the influence on fetus of the iron deficient pregnant rat, fed with iron deficient diet. On day 21st of gestation in normal pregnant rat, RBC, Ht and non-hemin iron of maternal liver are significantly lower than those of non-pregnant, but in iron deficient pregnant, those indexes as well as Hb are slightly but further decreased. We studied ferrokinetics with 59Fe specific binding transferrin by 59Fe-NTAmethod. Plasma iron disappearance rate T (1/2) was 97 minutes in non-pregnant, 25 minutes in normal pregnant and 22 minutes in iron deficient pregnant rat. It is significantly faster in pregnant than non-pregnant rat, but there was little difference between normal and iron-deficient pregnant rat. The mean body weight of fetuses was 4.5g in iron deficient pregnancies against significantly higher 5.2g in normal pregnancies. Hb and non-hemin iron of fetal liver were significantly decreased in iron deficient group. These result suggest that maternal iron utilization must be maintained at minimum level, so that supply of iron to fetus can be kept at maximum level. When pregnant rat is fed with iron deficient diet, there are some adverse influences on fetus, especially of intrauterine fetal growth retardation.
本实验的目的是了解用缺铁饮食喂养的缺铁妊娠大鼠对胎儿的影响。在正常妊娠大鼠妊娠第21天时，母体肝脏的红细胞、血细胞比容和非血红素铁显著低于非妊娠大鼠，但在缺铁妊娠大鼠中，这些指标以及血红蛋白均略有下降但进一步降低。我们采用59Fe-NTA法用59Fe特异性结合转铁蛋白研究了铁动力学。非妊娠大鼠的血浆铁消失率T（1/2）为97分钟，正常妊娠大鼠为25分钟，缺铁妊娠大鼠为22分钟。妊娠大鼠的血浆铁消失率明显快于非妊娠大鼠，但正常妊娠大鼠和缺铁妊娠大鼠之间差异不大。缺铁妊娠胎儿的平均体重为4.5克，而正常妊娠胎儿的平均体重明显更高，为5.2克。缺铁组胎儿肝脏的血红蛋白和非血红素铁显著降低。这些结果表明，母体铁的利用率必须维持在最低水平，以便向胎儿的铁供应能够保持在最高水平。当给妊娠大鼠喂食缺铁饮食时，会对胎儿产生一些不利影响，尤其是宫内胎儿生长迟缓。
