Brunello N, Cheney D L, Costa E
J Neurochem. 1982 Apr;38(4):1160-3. doi: 10.1111/j.1471-4159.1982.tb05364.x.
The present experiments were designed to test whether increasing the availability of choline to rat brain increases the rate of acetylcholine synthesis in that organ. The content of choline and acetylcholine and the turnover rate of acetylcholine in striatum, hippocampus, and cerebral cortex were measured following changes in dietary choline, intraperitoneal choline, or intravenous infusion of choline. Increasing plasma choline caused some increase in tissue choline but did not increase acetylcholine levels nor acetylcholine turnover rate in any of the areas of brain studied. Indeed, in hippocampus, choline decreased the turnover rate of acetylcholine.
本实验旨在测试增加大鼠脑内胆碱的可利用性是否会提高该器官中乙酰胆碱的合成速率。在改变膳食胆碱、腹腔注射胆碱或静脉输注胆碱后，测量纹状体、海马体和大脑皮层中胆碱和乙酰胆碱的含量以及乙酰胆碱的周转率。血浆胆碱增加导致组织胆碱有所增加，但在所研究的任何脑区中，均未提高乙酰胆碱水平或乙酰胆碱周转率。实际上，在海马体中，胆碱降低了乙酰胆碱的周转率。
