Ducobu J, Dupont P
Nouv Presse Med. 1982 Mar 13;11(12):915-6.
A retrospective study of 22 patients with hyponatraemia (less than 130 mEq/l) was conducted to find out whether hypouricaemia was useful in the diagnosis of SIADH. Serum levels of uric acid were inferior to 38 mg/l in 9 out of 12 patients with SIADH but not in the remaining 10 patients without SIADH. The mechanism of hypouricaemia in the syndrome seems to be an increase in uric acid excretion, since water restriction reduces the fractional clearance of urates. The authors conclude that hypouricaemia appears to constitute a reliable means of detecting SIADH in patients with hyponatraemia.
对22例低钠血症（低于130 mEq/l）患者进行了一项回顾性研究，以确定低尿酸血症在抗利尿激素分泌异常综合征（SIADH）诊断中是否有用。12例SIADH患者中有9例血清尿酸水平低于38 mg/l，而其余10例无SIADH的患者则未出现这种情况。该综合征中低尿酸血症的机制似乎是尿酸排泄增加，因为限水可降低尿酸盐的分数清除率。作者得出结论，低尿酸血症似乎是检测低钠血症患者是否患有SIADH的可靠方法。
