Leonard J C, Hitch D C, Manion C V
Radiology. 1982 Mar;142(3):773-6. doi: 10.1148/radiology.142.3.7063701.
A family of isotope elimination curves that reflects changes in the biodistribution of diethyl-IDA Tc 99m in neonatal cholestatic jaundice and biliary atresia is defined. Time/activity curves generated from equal areas over the heart and liver were evaluated separately and in conjunction with the scintigraphic data. Patients without scintigraphic evidence of significant hepatic uptake and with a hepatic curve that resembled the cardiac curve were found to have neonatal hepatitis. Good hepatic uptake and a hepatic curve with a terminal portion that appeared to be parallel to or divergent from the cardiac curve were associated with biliary atresia. Apparently converging hepatic and cardiac curves were associated with biliary patency. Although preliminary, these results provide further documentation that diethyl-IDA Tc 99m is useful in discriminating biliary atresia from other causes of cholestatic jaundice, while reducing radiation exposure and the need for pharmacologic intervention.
定义了一族同位素消除曲线，该曲线反映了二乙基亚氨基二乙酸（diethyl-IDA）锝99m在新生儿胆汁淤积性黄疸和胆道闭锁中的生物分布变化。分别并结合闪烁扫描数据评估了心脏和肝脏等面积区域生成的时间/活性曲线。未发现闪烁扫描有明显肝脏摄取证据且肝脏曲线类似于心脏曲线的患者患有新生儿肝炎。良好的肝脏摄取以及肝脏曲线终末部分似乎与心脏曲线平行或发散与胆道闭锁相关。肝脏和心脏曲线明显汇聚与胆道通畅相关。尽管这些结果是初步的，但它们进一步证明了二乙基亚氨基二乙酸锝99m在区分胆道闭锁与其他胆汁淤积性黄疸病因方面是有用的，同时减少了辐射暴露和药物干预的需求。
