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Corticosterone: a critical factor in an opioid form of stress-induced analgesia.

作者信息

MacLennan A J, Drugan R C, Hyson R L, Maier S F, Madden J, Barchas J D

出版信息

Science. 1982 Mar 19;215(4539):1530-2. doi: 10.1126/science.7063862.

DOI:10.1126/science.7063862
PMID:7063862
Abstract

The finding that some opioid-mediated forms of stress-induced analgesia are antagonized by hypophysectomy and dexamethasone has led to the suggestion that beta-endorphin, released from the pituitary, may mediate these analgesic reactions. "Long-term analgesia" (an opioid-mediated form of stress-induced analgesia), which is blocked by dexamethasone and hypophysectomy, was also blocked by adrenalectomy and reinstated with corticosterone therapy. Corticosterone is proposed to play a permissive role in long-term analgesia and to be a critical hormone mediating this phenomenon.

摘要

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引用本文的文献

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Effect of repeated morphine withdrawal on spatial learning, memory and serum cortisol level in mice.
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