Kiang D T, King M, Zhang H J, Kennedy B J, Wang N
Science. 1982 Apr 2;216(4541):68-70. doi: 10.1126/science.7063874.
Biological characteristics were assessed in GR mouse mammary tumors during 22 serial transplantations. Although unidirectional progression from hormone dependency to independency was observed, other biological markers such as progesterone receptors, polyploid frequency and thymidine kinase activity demonstrated cyclic phenomena every fourth to sixth transplant generation, suggesting the continued presence of regulatory mechanisms among various cells subpopulations.
