Ayalon A, Devitt P, Guzman S, Suddith R L, Rayford P L, Thompson J C
Surgery. 1982 Apr;91(4):399-401.
This study was designed to determine whether gastrin is released by the antrum in response to an intestinal meal in dogs. Two groups of anesthetized dogs were prepared with innervated antral pouches. The antrum and duodenum were separated by complete division at the pylorus to prevent duodenoantral reflux. The duodenum and proximal jejunum were perfused with 10% liver extract at 200 ml/hr. In one group of six dogs a significant elevation of antral vein gastrin levels was observed after 45 minutes. Gastrin levels in portal and peripheral blood were not significantly elevated. In another group of eight dogs, in which antral veins were not cannulated, a significant rise in peripheral gastrin concentration was noted after 60 minutes. We conclude that gastrin is released by the antrum during the intestinal phase of gastric acid secretion; significantly increased levels of gastrin are detected in both antral and peripheral venous blood. Duodenoantral reflux, as a possible cause of this release, is ruled out by complete surgical separation between duodenum and antrum.
本研究旨在确定狗的胃窦是否会因肠内进食而释放胃泌素。将两组麻醉的狗制备成带有神经支配的胃窦小袋。在幽门处完全切断胃窦和十二指肠，以防止十二指肠-胃窦反流。以200毫升/小时的速度向十二指肠和空肠近端灌注10%的肝提取物。在一组六只狗中，45分钟后观察到胃窦静脉胃泌素水平显著升高。门静脉和外周血中的胃泌素水平没有显著升高。在另一组八只未插管胃窦静脉的狗中，60分钟后外周胃泌素浓度显著升高。我们得出结论，在胃酸分泌的肠期，胃窦会释放胃泌素；在胃窦和外周静脉血中均检测到胃泌素水平显著升高。十二指肠-胃窦反流作为这种释放的一个可能原因，已通过十二指肠和胃窦之间的完全手术分离而被排除。
